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Cymbalta Side Effects

Cymbalta (generic name - duloxetine) is a relatively new medication. It was approved by the FDA in August 2004 as a treatment for major depression in adults, and in September 2004 for the management of diabetic peripheral neuropathic pain, a symptom of nerve damage that affects up to 5 million Americans.

Serious Cymbalta Side Effects

The following are considered to be possible serious Cymbalta side effects - an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);an irregular heartbeat or pulse; low blood pressure (dizziness, weakness); high blood pressure (severe headache, blurred vision); chills or fever; unusual bleeding or bruising; a rash or hives. If the patient experiences any of these, they should stop taking Cymbalta immediately and contact a doctor.

Less Serious Cymbalta Side Effects

The following are considered to be possible less serious Cymbalta side effects - headache, tremor, nervousness, or anxiety; difficulty concentrating; constipation; nausea, diarrhea, dry mouth, or changes in appetite or weight; weakness; increased sweating; sleepiness or insomnia; or decreased sex drive, impotence, or difficulty having an orgasm. Patients that experience any of these side effects can continue taking Cymbalta but be sure to let a doctor know.

It is quite possible for side effects other than those listed here to occur. If this happens and/or if any seem particularly strange or bothersome, contact a healthcare provider.

Special Cymbalta Precautions


Exercise caution when driving, operating machinery, or performing other hazardous activities as Cymbalta may cause dizziness or drowsiness. If you experience either, avoid these activities totally.

While taking Cymbalta, the patient may need to be monitored for signs of worsening symptoms of depression. This, especially important for Cymbalta patients who are 18 years of age or younger. The doctor may need to monitor for the following symptoms: anxiety, panic attacks, difficulty sleeping, irritability, hostility, impulsivity, severe restlessness, and mania (mental and/ or physical hyperactivity). These symptoms may be associated with the development of worsening symptoms of depression.

Before taking Cymbalta, the patient should let the doctor know if they - have liver disease; have kidney disease; narrow angle glaucoma; have diabetes; drink alcohol regularly; have high blood pressure; suffer from seizures; or suffer from mania or have suicidal thoughts. If any are true, the doctor may either adjust to a special dosage or not recommend Cymbalta at all.

Cymbalta is in the FDA pregnancy category C. This means that babies exposed to Cymbalta and/ or other drugs of the same class during the third trimester of pregnancy may develop medical complications. Thus, it is advised that you not take this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment. Cymbalta is also known to pass into breast milk and may affect a nursing infant.

Do not take Cymbalta if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) during the last two weeks. You should wait at least five days after you stop taking Cymbalta before taking a MAOI. Additionally, do not take Cymbalta if you are taking thioridazine (Mellaril).

If Cymbalta is taken with certain other prescription and non-prescription drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Lipitor with any of the following drugs - an antiarrhythmic such as flecainide (Tambocor) or propafenone (Rythmol), (and others); a tricyclic antidepressant such as amitriptyline (Elavil), imipramine (Tofranil), doxepin (Sinequan), nortriptyline (Pamelor), (and others); venlafaxine (Effexor); a phenothiazine such as chlorpromazine (Thorazine), fluphenazine (Prolixin), mesoridazine (Serentil), perphenazine (Trilafon), prochlorperazine (Compazine), (and others); a quinolone antibiotic such as trovafloxacin (Trovan), ciprofloxacin (Cipro), ofloxacin (Floxin), (and others); quinidine; or; a selective serotonin reuptake inhibitor (SSRI) such as fluoxetine (Prozac, Sarafem), paroxetine (Paxil, Pexeva), fluvoxamine (Luvox), and others.

Warning: This information is intended to supplement, not be a substitute for the expertise and judgment of a doctor. Please consult a doctor for final and more detailed information about the possible side effects of this prescription medication.
 
 
 
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